A possible solution: create a new layer and set it to donít plot. On that layer draw horizontal and vertical construction lines. All the drawing must be covered by a net having equal 8.5x11 cells (or a bit smaller, see bellow). Set the OSNAP to INTERSECTION. Go to the plot command and make the desired settings. In the PLOT AREA press the Window button and pick two diagonal corners of the first cell covering your drawing. After the drawing was sent to the plotter press ENTER to repeat the last command. Under the PAGE SETUP NAME select Previous Plot. Press WINDOW again and pick the corners of the next cell. One by one you can print all the drawing.
Because you canít print on the margins of the paper you should use smaller cells as the paperís dimensions.