Yes it is possible but why. A print house will charge you a nominal amount and will save you a lot of aggravation.
If you still want to do it, set your paperspace at 1:1 in a 24x36 sheet (or w/e sheet size you are using) and then draw 8.5x11(or actual printable area) squares on top of the paper space, then Print using each square as the boundary.



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