No, you can't move the WCS. The universe would implode
The only thing I can come up with right now (need more coffee) is changing the INSBASE of the drawings but even that might not work for you... especially if you are working with coordinates.
In my experience (and I don't know how many drawings you are dealing with) it would be better to do it right and move the drawing objects to where they need to be in relation to the WCS, and adjust your viewports. But someone else might have a better solution.