easy.... start a new file and get everything situated how you want it. (layers, dim/text styles, title block, plotting, etc). now Save As > AutoCAD Template File (has a *.dwt extension). save it in a default location, then go to the Files tab in Tools > Options, and under Template Settings > Default Template File Name for QNEW, locate the file. now everytime you start AutoCAD with New, it'll default to that.