Doesn't that depend on PICKADD value? I do believe the default is select to add and shift select to deselect from selection set.
To that end, it needs to be clarified from OP what they need, my WAG is something being already done with grread and need to deselect.
AFAIK (and that's very little, mostly from my previous thread )
The left click is doable with grread, but it would ignore the SHIFT (also CTRL, etc.), so probably would need something else to show the SHIFT key is pressed.
Which reminds me I need to get back to work on that and the centerline on rivers, roads, etc. problem when I get regular work caught up.